Skip to main content

New story in Health from Time: Remdesivir Shows Promising Results as a Coronavirus Treatment, According to Drug Manufacturer Gilead



Gilead, a California-based biopharmaceutical company, released two encouraging reports about remdesivir, an experimental drug that is being tested as a COVID-19 treatment.

In one statement, the company said that a large study of remdesivir “met its primary endpoint”: meaning, in this case, that the researchers have concluded that hospitalized patients taking the drug appear to improve faster than patients given a placebo. The study is run by the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health and involves severe patients at multiple centers across the country. Gilead has yet to release specific data from the study but noted in its release that NIAID is expected to provide more detailed results.

In another statement, the company released results from one of its two ongoing “SIMPLE” trials. One of these studies is designed to test remdesivir in people with moderate disease, and the other in those with more severe disease. Both compare a five day regimen to a 10 day regimen and do not include a placebo control. The company reported on the study involving nearly 400 people with severe COVID-19, who all had pneumonia and reduced oxygen levels but did not yet need to rely on a ventilator to breathe. In the study, the five-day regimen was deemed as effective as the 10 day protocol: after 14 days, 60% of those taking the drug for five days and 52% of those taking the drug for 10 days were discharged from the hospital.

The results add to the growing body of data suggesting remdesivir may be effective for treating COVID-19. Remdesivir was originally designed to treat Ebola, but studies in the lab showed it also acted against coronaviruses like SARS and MERS, so researchers began exploring its potential for treating COVID-19 when the pandemic began. It works by interfering with the virus’ ability to make more copies of itself.

No drug is currently approved to treat COVID-19, and ongoing studies are designed to test the effectiveness of promising candidates, like remdesivir, as well as their safety. Early hints of experimental drug’s potential benefit were leaked in April from a presentation by University of Chicago researchers; in that study, those assigned to receive remdesivir improved more quickly and were discharged from the hospital earlier than those getting placebo.

Another study conducted by Chinese researchers during the early days of the pandemic, however, showed that those taking remdesivir for up to 10 days did not show any quicker improvement than those randomly assigned to placebo. Gilead scientists note, though, that the study in China was suspended because the investigators could not enroll the intended number of patients with severe disease, suggesting the results may not be statistically significant. The Chinese researchers noted that they did see promising signs that people treated within 10 days of their first symptoms seemed to improve faster than those who began treatment 10 days after they experienced their first symptoms, a trend also found in the SIMPLE study.

While the current results are promising, until the complete data from the NIH study, as well as others that are ongoing around the world, are available, it remains unclear exactly what improvements remdesivir can provide in treating COVID-19, and which patients would most benefit from taking the drug.

Popular posts from this blog

New story in Health from Time: 3 More People Diagnosed With Coronavirus in Northern California

Three more people in Northern California have been diagnosed with the coronavirus known as 2019-nCoV, health officials in the area said Sunday, doubling the number of cases in the state and bringing the total across the country to 11 . The patients, whose symptoms are not yet serious enough to warrant hospitalization, are being kept in their homes, where they are being closely monitored, the San Francisco Chronicle reports . Two of the patients are a husband and wife from San Benito County. The husband fell ill after he returned home from Wuhan, China, where the outbreak began. It is believed he transferred the virus to his wife, who had not been to China. The other patient became sick while visiting family in Santa Clara County. She also previously visited Wuhan. Since arriving in the United States on Jan. 23, she has only left her home twice to seek out medical assistance. Officials from both counties said they are working to identify anyone who may have come into cont...

New video by blogilates on YouTube

Day 8 - 14 | Blogilates 2020 Challenge You guys are CRUSHING the #2020Challenge so far! Idk about you but my abs are soooooore! This week, we're doing 20 reps of abs every day + 20 reps of another new exercise every day! If you need a little extra motivation, text my number (510-692-4556) and tell me all about it so we can come up with a solution together! This link also works: https://ift.tt/2Qjqw7G This week's moves are: Jan. 8th (starts 0:48) - 20 butterfly bridges + 20 criss cross (butt + abs) Jan. 9th (starts 2:43) - 20 oil riggers + 20 rollovers (arms + abs) Jan. 10th (starts 8:29) - 20 lunges + 20 leg outs (legs + abs) Jan. 11th (starts 11:03) - 20 walnut crushers + 20 single leg drops (back + abs) Jan. 12th (starts 13:41) - 20 sprinters + 20 crunches (obliques + abs) Jan. 13th (starts 16:27) - 20 squat jumps + 20 russian twists (cardio + abs) Jan. 14th (starts 18:57) - 20 plank jacks + 20 butt ups (total body + abs) Here is where I get all of my music! Epidemic Sound: ...

New story in Health from Time: Coronavirus Cases Outside China Are Accelerating Rapidly. Here’s What to Know

A surge in deadly coronavirus cases outside China is raising concerns that the outbreak has reached a new stage and could continue its global spread to even more vulnerable countries. In the central Chinese province of Hubei, where the virus is believed to have originated, the number of cases appears to be stabilizing, according to government figures. But the number of people infected elsewhere in the world is rising quickly, with clusters in South Korea , Italy, Iran and a cruise ship docked in Japan. As of Monday, more than 2,200 cases of the virus, officially called COVID-19, have been reported outside of mainland China, where the overwhelming majority of the 79,000 cases have been located since officials first discovered the disease in December. The number of deaths outside China has also increased to 166, including 50 in Iran and four in Italy. In a news conference Monday, World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus said the WHO...